'Huge advance' in fighting world's biggest killer


An innovative new drug can prevent heart attacks and strokes by cutting bad cholesterol to unprecedented levels, say doctors.
The results of the large international trial on 27,000 patients means the drug could soon be used by millions.
The British Heart Foundation said the findings were a significant advance in fighting the biggest killer in the world.
Around 15 million people die each year from heart attacks or stroke.
Bad cholesterol is the villain in heart world - it leads to blood vessels furring up, becoming easy to block which fatally starves the heart or brain of oxygen.
It is why millions of people take drugs called statins to reduce the amount of bad cholesterol.
The new drug - evolocumab - changes the way the liver works to also cut bad cholesterol.
"It is much more effective than statins," said Prof Peter Sever, from Imperial College London.
He organised the bit of the trial taking place in the UK with funding from the drug company Amgen.
Prof Sever told the BBC News website: "The end result was cholesterol levels came down and down and down and we've seen cholesterol levels lower than we have ever seen before in the practice of medicine."

BBC NEWS


Islamic State: An invincible force?


In June 2014, so-called Islamic State (IS) took over the Iraqi city of Mosul. Within weeks, the organisation had swept through large swathes in Iraq and Syria, seizing a territory the size of the United Kingdom.
The territory IS controls has shrunk in the two years since a US-led multinational coalition launched an air campaign on its positions, first in Iraq and then Syria.
The coalition has managed to push IS out of the Iraqi cities of Tikrit and Ramadi, as well as an ever-increasing stretch of Syrian-Turkish borderland.
Enemies of the "caliphate", backed by (mostly) US fighter jets, are now bivouacked 50km (30 miles) from the IS "capital" of Raqqa, in northern Syria.
Yet IS' hold on its most valuable strategic terrain, the areas seized either in or before 2014, is still uncontested.
It is entrenched in Mosul and Raqqa and the Sunni Arab tribal heartland of the Euphrates river valley, which stretches from eastern Syria to western Iraq.
While it has lost much of the northern Syrian borderland, IS has also expanded into areas hitherto resistant to it, such as the Damascus suburbs and parts of the Aleppo countryside.

War spoils

IS' military arsenal consists of Russian and American weaponry mostly seized from government and rebel forces in both Iraq and Syria.
Its stockpiles include a fleet of Humvees seized after it defeated the US-equipped Iraqi army in Mosul and elsewhere.

The group's ability to acquire war spoils in the form of Russian and American tanks, recoilless rifles, rocket-launchers, light arms and ammunition was seriously diminished after it became harder to swiftly seize new territory.
When the campaign started in 2014, the US Central Intelligence Agency (CIA) said IS could muster between 20,000 and 31,500 fighters, up from an initial estimate of 10,000.
Despite over a year of air strikes, in February this year the White House said IS still had up to an estimated 25,000 fighters, mainly foreigners, from more than 90 countries.

Turning minds

Despite its fearsome reputation and initial shock grab of territory, IS is not invincible on the battlefield.
The bulk of its rank-and-file infantry, particularly foreign, do not fight well and are often dispatched by their native commanders as cannon fodder.
IS' most capable soldiers, its "special forces", have typically been Iraqi and Syrian militants with long experience of fighting in those countries, and graduates of other insurgencies, notably the Libyan-heavy al-Battar Brigade or the various units of militants from Chechnya or elsewhere in the Caucasus.
Where IS has excelled is in the realm of intelligence tradecraft.
This includes the maintenance of a highly elaborate and multilingual propaganda machine that caters to all constituencies, from American Muslims to Iraqi tribesmen.
Using bribery, blackmail and its own totalitarian form of cultural outreach, it has been able to win friends and influence people across thousands of square kilometres, often conquering a town, city or village long before its advancing columns lay siege to it.
IS dispatches cash-strapped sleeper agents into the ranks of its opposition, such as the Iraqi Security Forces or the Free Syrian Army, to slowly, covertly, buy or build a constituency.

Baathist core

IS is in many respects a project of Saddam Hussein's now-outlawed Baath Party, but with a different ideology.
Former agents or officers of the former Iraqi president's regime dominate its leadership.
For instance, Samir Abd Mohammed al-Khlifawi, better known as Hajji Bakr, was a colonel in Saddam's elite intelligence service of Saddam's Air Defence Force.
He was responsible for building IS' infrastructure in northern Syria in 2012 before being killed by anti-Assad rebels.
Another key IS figure was Abu Abdul Rahman al-Bilawi, a former captain in the Iraqi army. He was killed two days before the group's seizure of Mosul in June 2014, an operation whose final blitzkrieg he himself planned and so was accordingly dubbed "Bilawi Revenge".

Bilawi hailed from Iraq's Dulaim tribe, the country's largest. He was also quite close to Abu Musab al-Zarqawi, the founder of a precursor to IS.
A third ex-Baathist was Abu Ali al-Anbari, also once an intelligence officer in Saddam's army.
Anbari is the mastermind of the group's espionage and clandestine services, heading the IS Security and Intelligence Council and so tasked with running a vast honeycomb network of spies, operatives and sleeper cells, including those now active in countries beyond Iraq and Syria.
The ex-Baathists shape the group's jihadist ideology, handle its security (weeding out infiltrators or possible putschists) and military operations, and ensure its resilience.
They represent a battle-hardened and state-educated core that would likely endure (as they have done through US occupation and a decade of war) even if the organisation's middle and lower cadres are decimated.
Ex-Baathists have established an underground network, whose operatives are often disguised, even from other members.
This network of sleeper cells and security-minded members represent the organisation's core and, even if IS is defeated or contained militarily, will make it difficult to vanquish all together.
Hassan Hassan is an Associate Fellow at Chatham House, London, and a Resident Fellow at the Tahrir Institute for Middle East Policy, Washington; Michael Weiss is a senior editor at the Daily Beast.
BBC NEWS

Is so-called Islamic State finished?



Under fire from Russian, Turkish, Iraqi, Syrian and Kurdish forces, as well as US air power, so-called Islamic State has lost large swathes of land, as well as fighters and money. What does this mean for the Islamist militant group? Is it finished?
On 13 August this year, the town of Manbij in northern Syria was liberated from IS. After the last fighter left, the town erupted: men sat on street corners, cutting off each other's beards; women tore off their face veils and set fire to them; an old woman lit a cigarette and laughed through the smoke.
Previously, all of this was banned by IS.
IS has lost other towns too, such as Kobaneal-QaryatainTikrit and Fallujah.
But how much land has it lost in total? The risk consultancy group IHS produces maps to show which areas IS currently controls. It says that the amount of territory that IS has lost depends on how you are measuring.
"If you include the desert," says senior principal analyst Firas Abi Ali, "then it's lost around half of what it controlled a few years ago."
But it is perhaps more instructive to look at which cities it has lost. In losing towns such as Manbij, it has lost access to the Turkish border, which means the supply of foreign fighters, weapons and ammunition is drying up.
Losing cities means losing money too.
"When you control land and people, you gain access to revenue," says Firas Abi Ali. "You can extort the population. As it loses territory, it loses access to that pile of cash and it has less money available."
Firas Abi Ali estimates IS has lost about one-third of its capability to make money and predicts that the group will be defeated militarily by late 2017.
The big question now is whether IS can win back some of these cities, and the answer to that is partly about support.
Hassan Hassan's hometown in Syria was taken over by IS a few years ago, and he is now an analyst at the Tahrir Institute in Washington DC.
Over the past few years, he has been talking regularly to IS fighters online, and he says he has noticed something new.
"They're certainly worried," he says. "You get a sense that many people have lost the morale and the zeal that they had in 2014 when they joined because it was a 'caliphate' and it was expanding."
Now that the "caliphate" is shrinking, thousands of fighters are leaving. Along with those killed in battle, Hassan Hassan thinks IS has lost about half those who once fought for it.
Then there are those who did not fight for IS but supported or at least tolerated the group - not many, but enough to make it easier for IS to conquer so many towns. That is now changing too.
"People inside Syria and Iraq, they didn't understand [IS] in the beginning," he says. "They understand it today. People no longer talk about [IS] in the same way they talked about it in 2014."

IS itself seems to be accepting its new, weaker position. In its Arabic newsletter, the Dabiq, it is now talking about retreat. "They've started preparing their fighters psychologically for the retreat into the desert," says Hassan Hassan. "They're showing videos of IS members fighting in the desert, and these videos are new."
There are questions too about what this loss of land, fighters and money means for IS's ability to launch attacks.
Seth Jones, director of the International Security and Defense Policy Center at Rand Corporation think tank, has been studying IS documents found by Iraqi and US forces in Syria and Iraq.
"Islamic State is moving from an organisation that controls large amounts of territory into a terrorist group that is striking targets," he says.
In 2014, he says, every month there were about 150 to 200 attacks. In some months of 2016, there have been almost 400 attacks.
"They're trying to encourage people who believe the organisation is declining to continue to fight," he says. "To show that they still exist and they're still targeting 'the infidel'."
Other IS documents make it clear, he says, that the group wants to attack those countries involved in operations against it; such as the US, the UK and Australia. But with reduced finances, it will struggle to do so.
Increasingly, then, IS is relying on inspiring people to carry out attacks in its name, which means its leaders do not have to mastermind complex plots. IS is branching out too: into Nigeria, Afghanistan, Saudi Arabia, Algeria and Egypt, as well as parts of Europe. But there, too, it is under threat.
This raises a question: how long can IS keep inspiring attacks and spreading its ideology? Will there come a time when it runs out of steam?
"At some point those attacks will likely come down as the group begins to lose more broadly," says Seth Jones. "It's unclear when that will be for IS. I don't think it's there yet, but it's certainly possible in the near- to mid-term."
Many experts think it is now just a matter of time before IS loses its most important cities: Mosul in Iraq and Raqqa in Syria. If that happens, what then?
"Even if the territorial caliphate in Iraq and Syria is dismantled, this doesn't mean the end of the movement," says Fawaz Gerges, author of ISIS: A history.
Although IS shares some of its ideology with other militant groups, such as al-Qaeda, it differs in one key respect: it did not just talk about a caliphate; it conquered cities, erased borders and declared one. And in doing so, says Fawaz Gerges, it has energised global jihadism.
"The caliphate model will likely haunt the imagination of jihadists for many years to come," he says.
So where does all of this leave IS?
A year ago, no-one predicted IS would lose so much so quickly. And as it loses more land in the coming months, it is likely to lose more fighters. After all, what is Islamic State without a state?
So is Islamic State finished? Yes, it will lose its caliphate. But then the insurgency will begin.
The Inquiry: Is Islamic State finished? is broadcast on the BBC World Service. Listen online or download the programme podcast.
BBC NEWS

Tillerson: Military action against North Korea 'an option'


Military action against North Korea is "an option on the table", US Secretary of State Rex Tillerson has said during a visit to South Korea.
The policy of "strategic patience" had ended, he said, and the US was exploring a new range of diplomatic, security and economic measures.
He also defended the deployment of a US missile defence system in South Korea - a move that has angered Beijing.
Seoul and Washington say the system is needed to defend against North Korea.
Mr Tillerson spoke shortly after visiting the demilitarised zone which divides the two Koreas.
He arrived in South Korea from Japan, where he said that 20 years of efforts aimed at persuading North Korea to abandon its nuclear ambitions had failed.
Asked if the possibility for military action existed, he said: "Certainly we do not want to, for things to get to military conflict."
But he added: "If they elevate the threat of their weapons programme to a level that we believe requires action, then, that option's on the table."
He also called on China to fully implement sanctions imposed by the UN in response to North Korea's nuclear and missile tests.
"I don't believe we have ever fully achieved the maximum level of action that can be taken under the UN Security Council resolution with full participation of all countries," he said.
The US accuses China, North Korea's main ally, of not doing enough to rein it in. But Beijing remains wary of any action that could destabilise the North Korean regime and potentially create chaos on its border.
China is also strongly opposed to the deployment of the Terminal High Altitude Area Defense (Thaad) system in South Korea.
The US says the system is aimed at countering the threat from Pyongyang but China says its powerful radar will allow the US to spy on its territory.
In recent days there have been multiple reports of apparent economic retaliation aimed at South Korea by Beijing.
Rex Tillerson called these actions "unnecessary and troubling".
"We also believe it is not the way for a regional power to help resolve what is a serious threat for everyone," he said.
BBC NEWS

Mount Etna: BBC crew caught up in volcano blast


A BBC team and a number of tourists have suffered minor injuries after being caught up in an incident on the erupting volcano Mount Etna in Sicily.
"Many injured - some head injuries, burns, cuts and bruises," tweeted BBC science reporter Rebecca Morelle.
Lava flow mixed with steam had caused a huge explosion, which pelted the group with boiling rocks and steam, she said.
About eight people had been injured, with some evacuated from the mountain by rescue teams, she added."Bbc team all ok - some cuts/ bruises and burns. Very shaken though - it was extremely scary," she relayed in one of a series of tweets as she ran down the mountain.
The BBC reporter said a volcanologist at the scene told her it was the most dangerous incident he had experienced in his 30-year-career.

Lava ran into snow - Jonathan Amos, BBC science correspondent
Etna is one of the most active volcanoes in the world. That makes it a big draw not only for the scientists who want to understand better how these mountains work, but also for tourists who want to be amazed by a spectacular show of fire.
But you do not just wander up the mountain. If you're a reporter, you go with an experienced science team; if you're a tourist, you go with guides who are familiar with the sights and sounds that spell danger.
But even so, a volcano can often do something that catches everyone by surprise.
In this case a flow of lava ran into snow, producing superheated steam that sent fragments of rock flying in all directions. Everyone counts themselves lucky to have escaped with just cuts and bruises.
Rebecca Morelle's team was on site filming for a report about advances in volcano monitoring. What happened illustrates just how much we still need to learn about these mountains.
BBC

Senate intelligence panel rejects Trump wiretap claim


There are "no indications" that Trump Tower was under surveillance by the US government before or after the election, a Senate committee has said.
The statement from Republican Senator Richard Burr, Senate Intelligence Committee chairman, dismissed Donald Trump's claim his phones were tapped.
Mr Trump had accused his predecessor Barack Obama of wiretapping Trump Tower during the presidential race.
But White House spokesman Sean Spicer said Mr Trump maintains his claims.
"He stands by it," Mr Spicer said at a daily news briefing on Thursday.
The press secretary refused to accept the Senate Intelligence Committee report, saying "they're not findings".
Mr Spicer quoted at length from an unproven Fox News report suggesting Mr Obama had dodged US restrictions by asking Britain's GCHQ electronic surveillance agency to monitor Mr Trump, an allegation already dismissed as "utterly ridiculous" by the Cheltenham-based complex.
Mr Burr joins a cadre of Republican lawmakers who have rejected the allegation.
"Based on the information available to us, we see no indications that Trump Tower was the subject of surveillance by any element of the United States government either before or after Election Day 2016" Mr Burr said in a joint statement with Senator Mark Warner, the committee's vice-chairman.
Earlier on Thursday, House Speaker Paul Ryan also said "no such wiretap existed".
Republican chairman of the House intelligence committee Devin Nunes said on Wednesday he doesn't believe "there was an actual tap of Trump Tower".
But that has not deterred Mr Trump, who on Wednesday told Fox News a "wiretap covers a lot of different things".
He also hinted that more details about the alleged surveillance could be revealed in the coming weeks.
"Wiretap covers a lot of different things. I think you're going to find some very interesting items coming to the forefront over the next two weeks," he said in an interview broadcast on Wednesday night.

No evidence of wiretapping, according to:

  • former President Barack Obama
  • FBI Director James Comey
  • ex-Director of National Intelligence James Clapper
  • ex-CIA Director John Brennan
  • Republican chairman of House intelligence committee, Devin Nunes
  • Republican John McCain, who chairs Senate Committee on Armed Services
  • House Speaker Paul Ryan
  • Former White House Chief of Staff Denis McDonough

Mr Trump echoed comments from White House Press Secretary Sean Spicer, who said the president used the word "wiretap" in quotes to broadly refer to "surveillance and other activities".
The White House has yet to provide any evidence of the president's claims, and instead has asked Congress to examine the allegation as part of a wider investigation into alleged Russian interference in last year's election.
BBC NEWS

Apple to scan iPhones for child sex abuse images

  Apple has announced details of a system to find child sexual abuse material (CSAM) on customers' devices. Before an image is stored on...